This information is well worth repeating and comes from GeneWurx.com .If you plan to travel for business or just, for a visit to Egypt in the near future. You may wish to review a couple of other sites with travel information specific to Egypt Flutrackers.com and some of the related issues.
pH1N1 Demonstrates 95% Instability In Critical Genetics Range with Extensive Bird Flu Inclusions
Today, May 12, 2010, 5 hours ago | noreply@blogger.com (NS1)
In positions where this flu is revising the pandemic gene code, the ΣPF11 reservoir (pH1N1) presently exhibits a strong pattern of alliance with serotypes normally infecting birds, horses and dogs.
More than 95% of the Hemagglutinin positions between 186 and 246, including antigenic areas of the Receptor Binding Domain (RBD/RBS), are on record as polymorphic. Only 3 positions in that range are stable. Many positions rate multiple changes. Protein revision is documented at 45 of the 61 positions (73.8%), engaging the potential for antibody resistance (natural immune escape and vaccine escape).
Please recall from earlier analyses (linked in the ultimate paragraph) that individual single nucleotide polymorphisms (SNPs) have been correlated to escape events (low reactor).
The list presented today is certainly not comprehensive. Only one section is discussed from one gene segment (HA) covering 61 contiguous amino acid positions. The extensive variation in that short range is detailed in the data listing.
Viral revision is also rapidly occurring in additional HA antigenic areas outside the range of positions documented in this analysis. The Neuraminidase of the human pandemic H1N1 reservoir is also acquiring revisions with homology to Avian and Equine influenza at a ratio to total changes even higher than that of the Hemagglutinin being surveyed in this analysis.
The viral reservoir backing this present H1N1 flu pandemic is far from stable and is actively acquiring new genetics. Current data does not indicate an immediate direction toward stability.
A previous version of this listing may be referenced for tracking. Please review details on the causality behind this particular study in the earliest version.
186S synonymous (TCc) Russia61, BZSP53823_2009_08_01_f,
. . . . BadenWurttemberg8_2010, TexasJMS387_2009_12_08,
. . . . KO_Daegu1873_2009_12_16_TmX,
. . . . H9N2 (cCc, cac)
186P (cCT) CalifVRDL7, UkraineChernihiv857, Ankara17
. . . . Thessaloniki791_2010 mix (225G, syn233Y, 324I, 377K)
186F (TtT) Ankara26
187T synonymous (ACc) Berlin164, Iran572, BeijingXicheng11649,
. . . . S5, 1918,
. . . . H9N2
187A (gCT) TexasJMS405_2009, TexasJMS406_2009,
. . . . H5N1 (gaT)
188T (AcT) swThaiCURA75_2010_01,
. . . . H6N1 dkHK202_1977, dkKOS17_2003,
. . . . H7N7 extensive including human fatality
188S synonymous (AGc) NY6943_xL
188N SC16, SC31, NY3502, ME15, CatS1187, Milan433, Kaifu4142,
. . . . Bilthoven4360903023, Japan, China,
. . . . swHK_NS1809_2009_12_03 (189T), swHK_NS1810_2009_12_03
. . . . S5, H5N1
188I Growing in US on cross-linked background (4), BZSP53823 (186S),
. . . . H1N1 (1943, 46, 51)
189A synonymous (GCc), Georgia01_2010, Georgia 2010 (+5),
. . . . swOR4060
189V (GtT) Sydney2503, Texas46172731,
. . . . Sask, H6N1 mallMaryland887_2002
189S (tCT) Wisc1434
189T (aCT) Extensive in US incl NY7020 (77N), on cross-linkage (4) incl
. . . . NY6943_xL, Ontario328474, Aswan2288, China,
. . . . swHK_NS1809_2009_12_03 (188N)
. . . . 1918, H5N1 2009, H6N1, H9N2 2008
190D synonymous (GAt) Nebraska02_2010, Milan326, UkraineZakarpatska830,
. . . . AfghanN09833_2009_08
. . . . 1918, H1N1 (1943, 51)
190Y SwedenMalmoe1_2010_01_01, H6N1 (tTG)
191R (CgA) Chengdu18 (131P), GuangdongSWL28 (192H, 199N)
192H (CAt) GuangdongSWL28 (191R, 199N),
. . . . Avian H2N3 (agt), H3N8 (act), H6N1 (aAt, gat, gct)
192Q synonymous (CAg) RomaISS50 (227V), Nebraska01_2010,
. . . . H1N1 (1943, 46)
193S synonymous (AGc) US 2010 (4), SC18_VxX, NM11, NM13,
. . . . Wisc (5), DC_INS28,
. . . . CalifVRDL11_2010, CalifVRDL13_2010,
. . . . AfghanN10765_2009_09, Milan294, Japan 2010,
. . . . H3N8 AGc aplatBelgium12827_2007,
. . . . H6N1 AGc chkTaiwan0706_2003,
. . . . H9N2 Aac dkViet2009,
. . . . H11Nx Aac dkViet2009
193G (gGT) AR08, Cal_SDINS04, Kansas26,
. . . . H5N1 (gGg), H3N8 (gaT, gac, gaa), H11 (gac, gat)
193N (AaT) Washington72,
. . . . H3N8, H6N1, H9N2, H11
193R (cGT) catItaly304678_1_2009_12_17_f, Origin Unknown
194I (aTC) NC38E3, VA27, SC18, Bangladesh3009, StPete59, StPete99,
. . . . Thessaloniki788_2010 (syn233Y, 324I, 377K),
. . . . China (3),
. . . . H5N1
194L synonymous (CTa) Japan4081, tn,
. . . . H9N2 2008 (tTa),
. . . . H6N1 ckTaiwan1205_2001, tkBC2_1997 (CTa)
194L synonymous (CTt) TexasJMS385_2009, CalifVRDL36,
. . . . WiscD0675, WiscD0891, WiscD1237,
. . . . EgyptN11640_2009_10, Iran572,
. . . . H5N1,
. . . . H9N2 dkVietnamOIE2327_2009
195Y synonymous (TAc) Guayaquil4 (206S),
. . . . swOR4060, tkDeutsche, swDeutsche,
. . . . Avian H2N3,
. . . . Avian and Equine H3N8 emergent,
. . . . H5N1 gsEgyptR4_2007,
. . . . H6N1,
. . . . H7N7 2004-2009,
. . . . H9N2 99%,
. . . . H11 90%
196Q synonymous (CAa) Wisc (3), Moldova (3), Malaysia (2), China,
. . . . Milan326, Pavia (6), Ankara18, NordrheinWestfalen106,
. . . . swOR4060,
. . . . Avian H2N3,
. . . . H5N1
197T (AcT) Malaysia4039, swH1N2
198A synonymous (GCc) KO_Seoul1870_2009_12_18_TmX
198V Malaysia5283, Malaysia9117
198G (GgA) BeijingXuanwu1945 (86T, 178M), Tomsk07 (131P, 225G)
. . . . WSN33,
. . . . H3N8 eqHeilongjiang10_2008,
. . . . H6N1,
. . . . H7N7 ext
199N (aAT) GuangdongSWL28, Milan80, Milan83, Iceland176,
. . . . S9, S7, M7, Sask, H5 (aCT),
. . . . H1N1 (1943, 46, 51) (aCT)
199D synonymous (GAc) swine Illinois, H5, H9N2
200A synonymous (GCc) swOR4060, S5
200T (aCA) FL31, RomaniaTimis2018, Australia (6), Asia (15),
. . . . MilanUSHR1, Bilthoven4360901004,
. . . . NepalNP09A294, KO_Seoul1785_2009_11_TmX,
. . . . ShizuokaC247_2009_11_08,
. . . . Hiroshima647 (syn91G, 122E mix, syn145K, 210N mix, 219T mix),
. . . . Kobe90597_2010 (syn138A, syn429L),
. . . . Yokosuka8 (syn16T, 158E, 174R),
. . . . KuwaitN12991_2009_08_24,
. . . . tkDeutsche, swDeutsche,
. . . . H5,
. . . . H9N2
200S (tCA) NY1999_2010_01_18, NY0461, NY6945, NY5276,
. . . . NC57, SC46, WiscD0780, WiscS1338, NJ11, DC_INS31,
. . . . China,
. . . . MadridINS186 (373H), OdenseINS177 (286E)
. . . . cheetahCA30954
. . . . H11 Avian tCt ext, tCc ext including dkViet2009
201H (cAT) Wisc1140, Darwin2140,
. . . . H3N8 (cAa, cga), H7N7 (cta, ctg)
202A (GcT) MXinDRE797 2010 TmX (280A, syn321L, 324I), IA14, KY25,
. . . . HK34360, Guangdong2282 (131P, 230I, 244I, 275A),
. . . . LiaoningShuncheng1145, LiaoningShuncheng1148 (131P, 230I, 244I, 275A),
. . . . Bilthoven4310901550 (89G), Bilthoven4360903104 (89G),
. . . . H9N2 (AcA, AcG)
202V synonymous (GTa) JiangsuXiaguan1411
202V synonymous (GTc) YAMAGATA778, YAMAGATA803, swIllinois,
. . . . H1N1 (1943, 46, 51)
203S (TcT) Non-PF11 Sask, S9, S7, M7, 1918, WSN33
204V synonymous (GTa) PA31, SHIZUOKA1573, 1918, S7
204V synonymous (GTa) TexasJMS367_2009_11_12, PA31,
. . . . AfghanN10767_2009_09, AfghanN10974_2009_09,
. . . . KuwaitN13111_2009_09_23,
. . . . Shizuoka1573, Niedersachsen34, RheinlandPfalz86,
. . . . 1918, S9, S7, M7, Sask,
. . . . H9N2 Israel 2009, H9N2 Iran 2008
205G synonymous (GGa) Texas76C2, Wisc (4),
. . . . AfghanN09836_2009_08, TurkeyTR19_2009 (233H)
. . . . Slovenia5662, Slovenia5711,
. . . . Iceland162M (225G), Iceland162Siat3 (225G),
. . . . tkDeutsche, swDeutsche,
. . . . S5, H3N8 (tCa), H9N2 (GCa), H6N1 (GGa), H7N7 (GGa)
205E (GaG) BadenWurttemberg8_2010, ShizuokaC247_2009_11_08
. . . . Alabama03_2010_03_01 mix,
. . . . H11 (Gat), H7N7 (Gaa), H7N7 dkVictoria1976 (GaG)
205W (tGG) Brno216_2009, PuneNIV9433 (2E, 176I, 252L, 296H)
206A CatS1161
206T (ACA) Extensive
206T (ACt) Georgia670_2010 (Europe)
. . . . HiroshimaC309 (syn116R, 158E, 225E, 300S, 301V mix, syn398E)
207S synonymous (TCg) California01_2010,
. . . . CalifVRDL100 . . . (119M [H7N7], 189T [H5, H6, H9N2], 377K [H9N2]),
. . . . CalifVRDL12_2010 (119M [H7N7], 189T [H5, H6, H9N2], 377K [H9N2],
. . . . . . . . . . . . . . . . . syn477T [H3N8]),
. . . . CalifVRDL14_2010 (119M [H7N7], 189T [H5, H6, H9N2], 377K [H9N2],
. . . . . . . . . . . . . . . . . syn477T [H3N8]),
. . . . Avian H2N3,
. . . . H7N7 mallCalHKWF1971_2007 plus 5
208K (AaA) US, UK, Canada, HK, MX, Italy (2), Australia (12), Asia (5),
. . . . BahrainN11890_2009_10, BahrainN11892_2009_10, Dakar 2010 (3)
. . . . Cyprus5870_2010 (214R, 225E, 324I),
. . . . swOR4060
208S Australia43, Australia45, H6N1
208G (gGA) NY6292, HubeiWuchang1407,
. . . . Avian H4N6, H9N2 (gaA)
208T Norway3440
208R synonymous (AGg) TexasJMS385_2009
209Y synonymous (TAt) ShanxiWanbolin337
209D NorthDakota15
210S synonymous (AGt) Bogota0466N, Malaysia9131,
. . . . PuneNIV9436 (8V, 226R),
. . . . H9N2 (Aat)
210G (gGC) Bilthoven4360903119 (225E)
210N Texas76C2,
. . . . Hiroshima647 (syn91G, 122E mix, syn145K, 200T, 219T mix) mix,
. . . . H1N1 (1943, 46, 51)
211K (AAa) synonymous MXinDRE50617 (225G), Niedersachsen330
211R swOR4060_2009_12_31, 1918, H1N1 (1943, 46, 51)
212R swOR4060_2009_12_31, 1918, H1N1 (1943, 46, 51)
212E Vlad01 (225G), Argentina8574_41, IN21, HI30, Malaysia4039,
. . . . Latvia122498 (225G), Iwate1093
212N ME15
212T Anadyr177_F (225G), CA07X179, CA07X181
212K synonymous (AAa) NY1999_2010_01_18, NY0461, TexasJMS404_2009,
. . . . AfghanN11216_2009_10_16
213L TX15, Iowa04_2010, H5N1
213F synonymous (TTt) NY3230_2010_01_25 (100N, 159K), StPete99 (225E),
. . . . Sachsen156, IsraelMF4683, Georgia4805 (35I), Georgia670_2010 (165R)
214K synonymous (AAa) CalifVRDL81 (100N, 135I), San DiegoINS101_2009,
. . . . NY1999_2010 (syn429L), NM13,
. . . . Iran20001, Iraq2587, CatS1937, ENG620,
. . . . China22811, GuangdongFutian1480,
. . . . NagasakiHA1015_2010_02_01 (135E, 377K),
. . . . NagasakiHA1017_2010_02_08 (135E, 377K, syn496A, 550K),
. . . . S5,
. . . . H5N1 Aga
. . . . H9N2
214E Kurgan01, Moldova (3), swOR4060_2009_12_31
214N ENG92960012, SHIZUOKA1514, Hessen48
214Q Wisc0936 (237L)
214R (AgG) Cyprus5870_2010 (208K, 225E, 324I)
215P synonymous (CCa) NY2372_2010_01_20 (233H), San DiegoINS101_2009,
. . . . Kuwait (4), SC33, Eng616, BZ_Bahia15525_42M_f (RRT),
. . . . NepalNP09A284, Thai0440, GuangdongyunchengSWL51,
. . . . swHK_2299_2009_10_22, swHK_NS1583_2009_10_22
215P synonymous (CCt) NY_WC37RG, MO02, Eng256, Lisboa171 (324I, 373H)
216E synonymous (GAg) BadenWurttemberg490_xL, Hamburg14_xL,
. . . . Thuringen189_xL, Thuringen227_xL, Bilthoven4360903109,
. . . . Moldova (4), Belarus, Bosnia (3, 225G),
. . . . Bulgaria1369 (99T), Ostrava221_2010,
. . . . Iraq2587, Indiana,
. . . . tn, H9N2 (GTg)
217M (ATg) CalifVRDL99 with 4 potential zoonotic polymorphisms
. . . . (syn97D [H3N8 Avian, Equine & Canine, H5N1 Avian & Human],
. . . . .syn147F [H3N8 Avian, H4, H5N1, H6N1, H11],
. . . . .377K [H9N2],
. . . . .syn429L [H3N8 Avian])
. . . . H5N1 Human Indonesia 2006,
. . . . H5N1 Avian Bangladesh 2008
218A synonymous (GCg) Belarus, GhanaN12987_2009_10,
. . . . H9N2 (GGg), H6N1
218A synonymous (GCt) Nebraska02_2010, Iraq2587,
. . . . WSN33
218E Texas77 (159S, syn173G, 275A, 377K, 454I)
218S (tCA) Georgia07_2010 mix
218T (aCA) Hiroshima201 (225G), KuwaitN12991_2009_08_24
. . . . BelgiumG4751_2009 mix, Latvia237_2010 mix (377K)
218V (GTa) GuangdongyunchengSWL51, Malaysia (2 mix wt)
218V (GTc) swIll02930, 2931, 2932, 2937 (2009-12-29, 30)
219I synonymous (ATt) Calif_SDINS35, CalifVRDL84 (35I), NY6939 (35I),
. . . . Ancona451_f, Lyon2490, Poitiers3691 (35I), Valladolid35 (35I),
. . . . RheinlandPfalz81, Berlin210, BadenWurttemberg511,
. . . . Saarland21 (35I), Luxembourg184_2010 (35I), Luxembourg251_2010 (35I),
. . . . Dakar 2010 (4, 35I), Cameroon463 (35I),
. . . . H5N1 (Act), H6N1 (gct, gat)
219T (AcA) Wisc0134 (225E), Ontario315107 (225E),
. . . . RomaISS223, TessenderloINS191,
. . . . Hiroshima647 (syn91G, 122E mix, syn145K, 200T, 210N mix) mix,
. . . . Korea3623_2009_11_09 (131P, 226R, 280A),
. . . . swOR4060_2009_12_31
220R synonymous (AGg) Florida02_2010, Mexico476, MexCtCIA4,
. . . . Malaysia9451,
. . . . H6N1
221P synonymous (CCa) WiscD0780
221P synonymous (CCt) Non-PF11 tkDeutsche, swDeutsche
222R (AgA) ThaiTHB0405, ThaiTHB0408
223V synonymous (GTa) Utah59, ThaiTHB0390
. . . . H1N1 (1943, 1946, 1951),
. . . . H6N1 mallSweden30/2005
223M CA33
224K SC18_VxX, Melbourne1_1946
224M NY5186
225D synonymous (GAc) HubeiWuchang1418,
. . . . swHK_NS1809_2009_12_03, swHK_NS1810_2009_12_03
225N BZ_SP53838, Ukraine mix wt, Victoria2125, Malaysia8860
. . . . Neimenggu-Hangjinhouqi51, EgyptN14648_2009_11,
. . . . IrelandM79555, IrelandM79556,
. . . . BadenWurttemberg502, et al
225E Extensive on multiple backgrounds, incl Kuwait, Ghana and Egypt.
. . . . Denmark1341 (158E, 264V), Cyprus5870_2010 (208K, 214R, 324I),
. . . . LaReunion3479, Morocco1088H (300S),
. . . . HiroshimaC309 (syn116R, 158E, syn206T, 300S, 301V mix, syn398E)
225G LvivN6_VxX with syn413K, UkDnip273 (GgT mix wt),
. . . . YaroslavlIIV196_2009_12_04_f (89G & 4 silent H5N1 changes),
. . . . TurkeyTR20 (324I), Thessaloniki791_2010 mix (186P, syn233Y, 324I, 377K),
. . . . Latvia121488_2009 (377K), Georgia4484_2009 (158E, 377K),
. . . . Iceland162M, Iceland162Siat3, Denmark1900,
. . . . China mix,
. . . . NY7216 (148F),
. . . . H1N1 (1943, 46, 51),
. . . . H6N1,
. . . . H9N2
225G (Gga) RomaISS1897 & 1941, EgyptVacsera138,
. . . . EgyptN14644_2009_11_01, ex225E all with 300S, H6N1
225E+226R Russia (3), GermanyBY74, swMX4
226R synonymous (CAg) Alabama08, Texas45033567, Texas45131305,
. . . . S7, M7, S5, tn
226R Alabama01_2010, Trabzon01 (Turkey), GermanyMVHGW4_2009_12,
. . . . Korea3623_2009_11_09 (131P, 280A), China,
. . . . catItaly304678_2_2009_12_17_f, et al
227E synonymous (GAg) Wisc (10), Texas45130742,
. . . . Paris2573, Paris2590,
. . . . Avian H2 (Ggg)
227A swOR4060_2009_12_31, tkDeutsche, swDeutsche,
. . . . NJ11_1976_X53A, 1918,
. . . . H1N1 (1943, 46, 51)
227V (GtA) RomaISS50
227G (GgA) Utah20_VxX mix, Avian H2
228G synonymous (GGa) Arizona06, Lisboa108 (225E, syn346G),
. . . . Valladolid35 (35I),
. . . . GhanaFS1982 (syn139C, 206T, 261K, 296H, syn346G, 377K),
. . . . GhanaFS2206 (syn139C, 206T, 261K, 296H, syn346G),
. . . . ShanxiPingding351
. . . . S9, S7, M7, S5,
. . . . H5N1
229R synonymous (AGg) swMX04 (225G, 226R), SichuanDongqu1818,
. . . . H6N1
230I (ATc) Sask, S9, S7, H6N1 (4), H7N7
230I (ATa) Wisc0337_2009_12_15 (275A, 377K),
. . . . H1N1 (1943, 46, 51),
. . . . H5N1 Gharbiyah 80% CFR,
. . . . H3N8
230I (ATt) Guangdong2282 (131P, 202A, 244I, 275A),
. . . . LiaoningShuncheng1148 (131P, 202A, 244I, 275A),
. . . . H5N1, H6N1,
. . . . H7N7,
. . . . H9N2
230V (gTG) TexasJMS369_2009
231N synonymous (AAt) NY3230_2010_01_25 (100N, 159K),
. . . . CalifVRDL36 mix (273K), Lisboa104
231D Ankara05, OSAKA2143, GuangxiQinnan1187,
. . . . H6N1,
. . . . H9N2 2008
231K (AAa) Wisc0853, Wisc1915, Wisc2337
. . . . WiscD0740 (22I, 176I, 188I, 277N, syn413K)
232Y synonymous (TAc) NY7216 (148F, 225G), TexasJMS386_2009,
. . . . Florida30, PuertoRico51,
. . . . S9, S7, M7, Sask,
. . . . H5N1, H6N1,
. . . . H9N2
233Y synonymous (TAt) AthensINS85,
. . . . Thessaloniki788_2010 (194I, 324I, 377K),
. . . . Thessaloniki791_2010 mix (186P, 225G, 324I, 377K),
. . . . Hiroshima645,
. . . . H6N1,
. . . . H9N2 2008
233H (cAC) NC Duke TmX cluster (5, mix, 225G, 225N), NY2372_2010_01_20,
. . . . AZ17 & Australia6, TurkeyTR19_2009 (syn205G),
. . . . swHK_189_2010_01_07
235A CatNS7632, CalifVRDL55
235I Wisc2489
236L synonymous (CTg) Wisc0099, H9N2 (gTg)
236V Eng93120020, ENG645, H9N2, H6N1
237I Delaware02_2010, Cal_SDINS69, England (2),
. . . . Russia (4), Asia (4), MadridINS185 (447K)
237L Wisc0936 (214Q), 1918, H1N1 (1943, 46, 51),
. . . . tn, H5N1, H6N1,
. . . . H9N2
237V synonymous (GTg) Pennsylvania31, KuwaitN13111_2009_09_23,
. . . . AfghanN10767_2009_09, AfghanN10974_2009_09,
. . . . H9N2 (TTg), M7 (CTg)
238G (GgG) AthensINS161 (89G, 152L)
238D Kaliningrad01 (225E+226R), tn
238K (aAG) Wisc2485 (225E), DjiboutiN13142_2009_12_08, Spain (3),
. . . . OrenburgIIV13_2010_03_02_xL_f (225G), China,
. . . . swOR4060,
. . . . H1N1 Iowa_1943,
. . . . H5N1, H6N1,
. . . . H9N2 2008
238E synonymous (GAa) Extensive Wisc2424, EgyptN14648_2009_11,
. . . . Latvia122498, ThaiTHA0364, ShanxiChengqu547,
. . . . Cyprus5800_2010, HvidovreINS141,
. . . . SC01_2010, MN01_2010,
. . . . H9N2 (aAa), H6N1 (aAa)
239P synonymous (CCt) ENG621, NY6939, swOR4060_2009_12_31
239P synonymous (CCa) Ancona508PG, Russia180, Australia60,
. . . . MS09, NV20, ME01_2010, tn,
. . . . H6N1
. . . . H9N2
240G synonymous (GGg) DC_INS24,
. . . . S9, S7, M7, Sask,
. . . . H6N1 (GGg),
. . . . H9N2
240G synonymous (GGc) Wisc0636,
. . . . H9N2 (GGc)
240E (GaA) Brandenburg34
241D synonymous (GAt) CatS1943, Colombia4117, swIll (3), S7, M7, tn, H5
241G NH17, ENG93040048
241E China22811, H9N2 (CAa, CAg), H6N1 (GAa, GAg)
242K synonymous (AAg) swOR4060_2009_12_31
244I ThaiCU_H9, Shiga1, Guangdong2282 (131P, 202A, 230I, 275A),
. . . . LiaoningShuncheng1148 (131P, 202A, 230I, 275A),
. . . . Ancona02, Stockholm29,
. . . . Alabama03_2010,
. . . . H1N1 (1946, 51), S9, S7, M7, Sask
244T synonymous (ACt) CatS1935, CatS2120
245F synonymous (TTt) Aswan2288 (189T, 377K)
246E synonymous (GAg) NorthCarolina56 (100N, syn137A, 377K),
. . . . S7, M7, 1918, tn,
. . . . H5N1
246G (GgA) Iceland163_2009 mix (159D)
The truth is in the sequences
Wednesday, May 12, 2010
Thursday, April 29, 2010
Pandemic Influenza H1N1 Genetic Acquisitions
I have great respect for the efforts of the individual behind the report below.which is complete as penned.Its well worth reading and weighing the contained information.
Pandemic Influenza H1N1 Genetic Acquisitions
Today, April 29, 2010, 14 hours ago
Zoonotic H9N2 Avian Influenza Further Destabilises H1N1 Pandemic Genetics
Today, April 29, 2010, 14 hours ago | noreply@blogger.com (NS1)
Is the H1N1 Pandemic Influenza Reservoir Stable?
If you enjoy counting, even measuring by observation, please continue reading.
But you must realize that the iota, the jot and even the title, will be considered of value in this forthcoming exercise. Some in the science community appear to find the process of discovery by observation just too tedious. If you are of that mindset, please direct your attention to any of the many “Science for Hire” venues where illogical, but comforting, summations are drawn from cleverly manipulated data streams. Science sells today. But we sometimes speculate that science is becoming just another sell-out, an industry pursuing profit over knowledge?
On the other hand, if careful examination, even hard work, is part of your daily lab book, you'll find evidence in this discussion to introspect.
Leading public health officials continue even today to indicate that the pandemic virus is unchanged. Keep that statement in mind as you read this analysis of heavy change activity in the pandemic reservoir, watching closely for the recent branching into genetic areas matching H9N2.
Also keep in mind that even single changes have demonstrated substantial importance.
Ongoing worldwide studies duplicated by independent, geographically dispersed laboratories, including the labs of those noted public health officials, indicate that a single polymorphism may produce a significant outcome within a Pandemic Influenza reservoir. Numerous accounts of important revisions are on record across a vast geography. The HA gene segment provides suitable examples for this discussion. 225G has produced a Vaccine Escape event in LvivN6, an elevated Case Fatality Rate and a substantial number of severe outcomes. Individual changes from 157 to 159 have also demonstrated “low reactor” status and registered as Vaccine Escape events. When 230I entered the H5N1 Gharbiyah cluster in Egypt, the resultant Case Fatality Rate became 80% for that strain, a substantial increase from the accepted H5N1 CFR.
Three separate single genetic changes are well characterised in leading to various forms of Anti-Viral resistance. TamiFlu Resistance (TmX) has now dispersed widely in a pattern following the rapid spread of resistance in seasonal influenza via the same Single Nucleotide Polymorphism coding for 275Y on the Neuraminidase. Emergent and attractant H1N1 strains (Triple Reassortments again) co-circulating alongside the pandemic reservoir also carry 275Y. H5N1 inclusions increase in the pandemic reservoir with a continuous flow. The PB2 627K is confirmed as leading to increased replication speed in humans and has recently been documented in a second pandemic sequence. As we have maintained from the beginning of this pandemic, TamiFlu Resistance and 627K are foregone conclusions according to our calculations.
Our team noted an increase in Avian inclusions and recently predicted HA 230I for ΣPF11. The polymorphism was documented last week in Wisconsin (US) on a background that does not deter transmission. The geographic area has a notable increase in cross-linked activity. The individual sample, A/Wisconsin/629-D00337, is primed for spread with 2 additional HA markers, 275A (TX, NM, CA and Sweden) and 377K (aggressively emerging). The NA carries 220K, a marker found on one cross-linked sequence from the Ukraine and across a wide US geographic pattern from December 2009 to the most recent 2010 sequences (North Carolina, New Hampshire, Wisconsin and Nebraska). The H6N1 Avian reservoir conserves 220K on the NA of 6 samples. We consider the Wisconsin0337 sample to be an excellent candidate as a universal donor of sorts due to limited polymorphisms, FlightPath intersecting location and the fact that each revision is currently an emergent change.
A second variant of 230I has been recorded from southern China with A/Guangdong/2282. Though the underlying 230I nucleotide coding and the overall background is different from the Wisconsin0337 sequence, Guangdong2282 remarkably carries the extremely rare 275A, a permutation found in less than ten samples within this pandemic reservoir. Guangdong2282 displays a highly polymorphic HA with 131P, 202A, 230I, 244I and 275A. All but 131P are rare. 202A is only found on one other human pandemic sequence, a 2010 TamiFlu Resistant case from Mexico. Two of the four NA changes match 1918 (53I, syn315G) with potential H5N1 involvement on one other. Convergence of numerous rare polymorphisms, including potential acquisitions from H5N1, H6N1, H9N2 and 1918, informs us that the viral reservoir is amply supplied for variation and is adamant about exercising fresh patterns.
H9N2, a "bird flu" serotype, has been recently evaluated for human pandemic potential. By all appearances, the present H9N2 reservoir is not becoming a pandemic virus, but is very much influencing the genetic acquisition cycle of the currently circulating PF11 pandemic virus (pH1N1). Which is worse, another species-jumping serotype entering the fray or a combinational virus with genetics from multiple pandemic potential reservoirs appending onto the current partially-adapted virus? In either case, the Hydra Effect appears to be operating in full force.
Given this information, obvious questions begin to form. If one genetic change may potentiate variant clinical outcomes, drug resistance or Vaccine Escape, what is the potential for multiple changes producing a variant outcome? And if a single genetic change and/or multiple changes are capable of producing large changes in behaviour, should we, in turn, have a very high and accurate level of surveillance on this reservoir? And what should we do with that important information? Should our public health officials speak from a platform of candor and accuracy when carrying out the responsibilities of their trusted positions?
Let’s investigate now if the viral reservoir is, in fact, unchanged?
Approximately 86% of the Hemagglutinin positions between 186 and 244, including antigenic areas of the RBD, are on record as polymorphic. Only 8 positions in that range are stable. Many positions rate multiple changes. The list presented today is certainly not comprehensive. For the sake of brevity, only one section is discussed from one gene segment (HA) covering just 59 amino acid positions. The extensive variation in that short range is documented in the trailing data. Tracking these revisions against various baselines has informed our studies over the past year.
The positional summary may perhaps be instructive for those who hold the belief that the pandemic reservoir is stable. This report may provide reversing guidance for those who make public statements to the effect that pandemic H1N1 is not changing. Although their multiple motivations to transmit these types of false “Feel Good” statements are somewhat discernable, the citizen requires the full story, the truth, to make informed decisions.
Those making these statements do, in fact, understand Primary Logic and Basic Science; they do know that for a vaccine to be considered widely useful, the viral reservoir must be cooperative and unchanging. They also know that this reservoir is vastly changed. However, their jobs depend on providing a social message with a stated solution. Knowing that the vaccine is not useful against this present changed virus, they must by now realise that they have lost their stated solution. The traditional public health strategy in these solution-less situations is obfuscation. Re-education on basic fact, re-definition of truth, has now become the chief tenet, their tool of choice, to bridge that failure to solve.
Science solves . . . crafting a clever press release is not an act of science.
The official repetition of the “All Clear” social messaging campaign cannot reverse the weight of the actual data. The presently circulating virus is hereby documented in this report as changed and changing. No amount of repetition invoking the “unchanged” myth, that mystical “Feel Good” chant, can conjure an environment that miraculously creates a stable viral reservoir or that alters the ongoing genetic acquisition cycle.
However, that ongoing strategy of repetition is apparently very effective in managing the perception and manipulating the belief of the unsuspecting public. Sleight of hand is always discovered on careful observation . . . but will this reliance on myth be discovered soon enough?
Observe.
The viral reservoir backing this present H1N1 pandemic is far from stable and is actively acquiring new genetics. Current data does not indicate an immediate direction toward stability.
As is the nature with an IDRREAV, the positions reported here will not necessarily be the most important amino acid positions in the future. The reservoir will evade immunity and escape vaccine by heavily self-revising in the near future at key locations between 131 and 182 (emphasis at 155 to 177). Variation will occur with lower penetration at the head of the HA and from 272 downstream approximately 55 positions. Potential is very high that 22I will achieve density in one or more sub-clades. Expect 100N to spread and penetrate initially on sub-clades without the 22I appearances. South American polymorphisms from their fatal mid-pandemic strains of 2009 will recycle into the United States and other Northern Hemisphere nations with substantial thrust in the coming 90 days. Acceleration of the Avian based cross-linking will continue in the Western world.
Bear in mind also that a solid portion of the changes documented in this current list will become fixed even as additional donations are accumulated. The zoonotic movement from birds into human PF11 sequences is earnestly progressing in the most recent 45 days of available data. Several polymorphisms, HA and NA, from the recent 2010 Georgia hospitalization resurgence may have originated in Avian Influenza samples.
Expect continued acquisition from Avian H5N1, H6N1 and H1N1, and also watch the acceleration from one particularly new Avian donor serotype. H9N2 demonstrated a human jump in late 2008 and has very recently become fully engaged in ΣPF11 genetics with a well-defined etching on the newest cross-linked sequences. The reservoir flux will also be influenced by Swine H1N2 and H1N1 (emphasis on 3 certain emergent strains).
Is the Pandemic Influenza Reservoir Stable?
You decide . . .
186S synonymous (TCc) Russia61, BZSP53823_2009_08_01_f,
. . . . BadenWurttemberg8_2010, TexasJMS387_2009_12_08,
. . . . KO_Daegu1873_2009_12_16_TmX,
. . . . H9N2 (cCc, cac)
186P (cCT) CalifVRDL7, UkraineChernihiv857, Ankara17
186F (TtT) Ankara26
187T synonymous (ACc) Berlin164, S5, 1918, H9N2
187A (gCT) TexasJMS405_2009, TexasJMS406_2009, H5 (gaT)
188T swThaiCURA75_2010_01
188N SC16, SC31, NY3502, ME15, CatS1187, Milan433, Kaifu4142,
. . . . Japan, Bilthoven4360903023, S5, H5
188I Growing in US on cross-linked background (4), BZSP53823 (186S),
. . . . H1N1 (1943, 46, 51)
189V Sydney2503, Texas46172731, H6N1 mallMaryland887_2002, Sask
189S Wisc1434
189T Extensive in US, on cross-linkage (4), Ontario328474
. . . . H5N1 2009, H6N1, H9N2 2008
189A synonymous (GCc), Georgia01_2010, Georgia 2010 (+5), swOR4060
190D synonymous (GAt) Nebraska02_2010, Milan326, UkraineZakarpatska830,
. . . . 1918, H1N1 (1943, 51)
190Y SwedenMalmoe1_2010_01_01, H6N1 (tTG)
191R Chengdu18 (131P), GuangdongSWL28
192H GuangdongSWL28
192Q synonymous (CAg) RomaISS50, Nebraska01_2010, H1N1 (1943, 46)
193S synonymous (AGc) SC18, US 2010 (4), Milan294, Japan, H9N2
193G (gGT) AR08, Cal_SDINS04
193N Washington72, H9N2
193R (cGT) catItaly304678_1_2009_12_17_f
194I NC38E3, VA27, SC18, Bangladesh3009, StPete59, StPete99
194L synonymous (CTa) Japan4081, tn
. . . . H9N2 2008 (tTa), H6N1 chkTaiwan1205_2001 (CTa)
194L synonymous (CTt) TexasJMS385_2009,
. . . . H9N2 dkVietnamOIE2327_2009
196Q synonymous (CAa) Wisc (3), Moldova (3), Malaysia (2), Milan326,
. . . . Pavia (6), Ankara18, NordrheinWestfalen106, swOR4060
197T Malaysia4039
198A synonymous (GCc) KO_Seoul1870_2009_12_18_TmX
198V Malaysia5283, Malaysia9117
199N GuangdongSWL28, Milan80, Milan83, S9, S7, M7, Sask, H5 (aCT),
. . . . H1N1 (1943, 46, 51) (aCT)
199D synonymous (GAc) swine Illinois, H5, H9N2
200A synonymous (GCc) swOR4060, S5
200T (aCA) FL31, RomaniaTimis2018, Australia (6), Asia (13),
. . . . MilanUSHR1, Bilthoven4360901004,
. . . . ShizuokaC247_2009_11_08, H5, KO_Seoul1785_2009_11_TmX,
. . . . tkDeutsche, swDeutsche,
. . . . H9N2
200S (tCA) NC57, SC46, WiscD0780, WiscS1338, NY5276, NJ11,
. . . . DC_INS31, cheetahCA30954
201H (cAT) Wisc1140, Darwin2140, H3N8 (cAa, cga), H7N7 (cta, ctg)
202A (GcT) MXinDRE797 2010 TmX (280A, syn321L, 324I), IA14, KY25,
. . . . HK34360, Guangdong2282 (230I, 275A),
. . . . Bilthoven4310901550 (89G), Bilthoven4360903104 (89G),
. . . . H9N2 (AcA, AcG)
202V synonymous (GTc) YAMAGATA778, YAMAGATA803, swIllinois,
. . . . H1N1 (1943, 46, 51)
204V synonymous (GTa) PA31, SHIZUOKA1573, 1918, S7
204V synonymous (GTa) TexasJMS367_2009_11_12, PA31,
. . . . Shizuoka1573, Niedersachsen34, RheinlandPfalz86,
. . . . 1918, S9, S7, M7, Sask,
. . . . H9N2 Israel 2009, H9N2 Iran 2008
205E (GaG) BadenWurttemberg8_2010, ShizuokaC247_2009_11_08
. . . . Alabama03_2010_03_01 mix,
. . . . H11 (Gat), H7N7 (Gaa), H7N7 dkVictoria1976 (GaG)
205G synonymous (GGa) Texas76C2, Wisc (4), tkDeutsche, swDeutsche,
. . . . S5, H3N8 (tCa), H9N2 (GCa), H6N1 (GGa), H7N7 (GGa)
206A CatS1161
206T Extensive
207S synonymous (TCg) California01_2010
208K US, UK, Canada, HK, MX, Italy (2), Australia (12), Asia (3), swOR4060
208S Australia43, Australia45, H6N1
208G NY6292
208T Norway3440
208R synonymous (AGg) TexasJMS385_2009
209D NorthDakota15
210G (gGC) Bilthoven4360903119 (225E)
210S synonymous (AGt) Bogota0466N, Malaysia9131, H9N2 (Aat)
210N Texas76C2, H1N1 (1943, 46, 51)
211K synonymous MXinDRE50617 (225G)
211R swOR4060_2009_12_31, 1918, H1N1 (1943, 46, 51)
212R swOR4060_2009_12_31, 1918, H1N1 (1943, 46, 51)
212E Vlad01 (225G), Argentina8574_41, IN21, HI30, Malaysia4039
212N ME15
212T Anadyr177_F (225G), CA07X179, CA07X181
212K synonymous (AAa) TexasJMS404_2009
213L TX15, Iowa04_2010, H5
213F synonymous StPete99 (225E)
214E Kurgan01, Moldova (3), swOR4060_2009_12_31
214N ENG92960012, SHIZUOKA1514, Hessen48
214Q Wisc0936 (237L)
214K synonymous (AAa) San DiegoINS101_2009, NM13, CatS1937,
. . . . ENG620, China22811, S5, H9N2
215P synonymous (CCa) San DiegoINS101_2009, SC33, Eng616,
. . . . GuangdongyunchengSWL51, BZ_Bahia15525_42M_f (RRT)
215P synonymous (CCt) NY_WC37RG, MO02, Eng256
216E synonymous (GAg) BadenWurttemberg490_xL, Hamburg14_xL,
. . . . Thuringen189_xL, Thuringen227_xL, Bilthoven4360903109,
. . . . Moldova (4), Belarus, Bosnia (3, 225G), Indiana, tn, H9N2 (GTg)
218A synonymous (GCg) Belarus, H9N2 (GGg), H6N1
218A synonymous (GCt) Nebraska02_2010
218E Texas77 (159S, syn173G, 275A, 377K, 454I)
218S (tCA) Georgia07_2010 mix
218T Hiroshima201 (225G)
218V (GTa) GuangdongyunchengSWL51, Malaysia (2 mix wt)
218V (GTc) swIll02930, 2931, 2932, 2937 (2009-12-29, 30)
219I synonymous (ATt) Cal_SDINS35, Ancona451_f, Lyon2490,
. . . . RheinlandPfalz81, Berlin210, BadenWurttemberg511,
. . . . H5 (Act), H6N1 (gct, gat)
219T (AcA) Wisc0134 (225E), Ontario315107 (225E), RomaISS223,
. . . . Korea3623_2009_11_09 (131P, 226R, 280A), swOR4060_2009_12_31
220R synonymous (AGg) Mexico476, Malaysia9451, H6N1
223V synonymous (GTa) Utah59, H1N1 (1943, 46, 51),
. . . . H6N1 mallSweden30_2005
223M CA33
224K SC18_VxX, Melbourne1_1946
224M NY5186
225N BZ_SP53838, Ukraine mix wt, Victoria2125, Malaysia8860 et al
225E Extensive on multiple backgrounds
225G LvivN6_VxX with syn413K, UkDnip273 (GgT mix wt),
. . . . H1N1 (1943, 46, 51), H9N2, H6N1
225G RomaISS1897 & 1941, EgyptVacsera138 (300S) ex225E (Gga), H6N1
225E+226R Russia (3), GermanyBY74, swMX4
226R Alabama01_2010, Trabzon01 (Turkey), GermanyMVHGW4_2009_12,
. . . . Korea3623_2009_11_09 (131P, 280A), catItaly304678_2_2009_12_17_f, et al
227A swOR4060_2009_12_31, NJ11_1976_X53A, 1918,
. . . . H1N1 (1943, 46, 51)
227V RomaISS50
227G Utah20 with wt mix
229R synonymous (AGg) swMX04 (225G, 226R), H6N1
230I Wisc0337_2009_12_15 (275A), Guangdong2282 (131P, 202A, 275A),
. . . . H1N1 (1943, 46, 51), H5 Gharbiyah 80% CFR, H9N2, H6N1
230V (gTG) TexasJMS369_2009
231D Ankara05, OSAKA2143, H9N2 2008, H6N1
231N CalifVRDL36
231K Wisc0853, Wisc1915, Wisc2337
232Y synonymous (TAc) TexasJMS386_2009, Florida30, PuertoRico51, S9, S7, M7, Sask,
. . . . H9N2, H5, H6N1
233Y synonymous (TAt) AthensINS85, Hiroshima645, H9N2 2008, H6N1
233H NC Duke (5, wt, 225G, 225N), AZ17 & Australia6
235A CatNS7632, CalifVRDL55
235I Wisc2489
236L synonymous (CTg) Wisc0099, H9N2 (gTg)
236V Eng93120020, ENG645, H9N2, H6N1
237I Delaware02_2010, Cal_SDINS69, England (2), Russia (4), Asia (2)
237L Wisc0936 (214Q), 1918, H1N1 (1943, 46, 51),
. . . . tn, H5, H9N2, H6N1
237V synonymous (GTg) Pennsylvania31, H9N2 (TTg), M7 (CTg)
238D Kaliningrad01 (225E+226R), tn
238K (aAG) Wisc2485 (225E), Spain (2), China,
. . . . OrenburgIIV13_2010_03_02_xL_f (225G), swOR4060,
. . . . Iowa_1943, H5, H9N2 2008, H6N1
238E synonymous (GAa) Extensive Wisc2424, SC01_2010, MN01_2010,
. . . . H9N2 (aAa), H6N1 (aAa)
239P synonymous (CCt) ENG621, swOR4060_2009_12_31
239P synonymous (CCa) Ancona508PG, Russia180, Australia60, ME01_2010, tn,
. . . . H9N2, H6N1
240G synonymous (GGg) DC_INS24, H9N2, H6N1 (GGg), S9, S7, M7, Sask
240G synonymous (GGc) Wisc0636, H9N2 (GGc)
240E (GaA) Brandenburg34
241D synonymous (GAt) CatS1943, tn
241G NH17, ENG93040048
241E China22811, H9N2 (CAa, CAg), H6N1 (GAa, GAg)
242K synonymous (AAg) swOR4060_2009_12_31
244I ThaiCU_H9, Guangdong2282 (131P, 202A, 230I, 275A), Shiga1,
. . . . Ancona02, Stockholm29,
. . . . Alabama03_2010, H1N1 (1946, 51), S9, S7, M7, Sask
244T synonymous (ACt) CatS1935, CatS2120
The truth is in the sequences.
Pandemic Influenza H1N1 Genetic Acquisitions
Today, April 29, 2010, 14 hours ago
Zoonotic H9N2 Avian Influenza Further Destabilises H1N1 Pandemic Genetics
Today, April 29, 2010, 14 hours ago | noreply@blogger.com (NS1)
Is the H1N1 Pandemic Influenza Reservoir Stable?
If you enjoy counting, even measuring by observation, please continue reading.
But you must realize that the iota, the jot and even the title, will be considered of value in this forthcoming exercise. Some in the science community appear to find the process of discovery by observation just too tedious. If you are of that mindset, please direct your attention to any of the many “Science for Hire” venues where illogical, but comforting, summations are drawn from cleverly manipulated data streams. Science sells today. But we sometimes speculate that science is becoming just another sell-out, an industry pursuing profit over knowledge?
On the other hand, if careful examination, even hard work, is part of your daily lab book, you'll find evidence in this discussion to introspect.
Leading public health officials continue even today to indicate that the pandemic virus is unchanged. Keep that statement in mind as you read this analysis of heavy change activity in the pandemic reservoir, watching closely for the recent branching into genetic areas matching H9N2.
Also keep in mind that even single changes have demonstrated substantial importance.
Ongoing worldwide studies duplicated by independent, geographically dispersed laboratories, including the labs of those noted public health officials, indicate that a single polymorphism may produce a significant outcome within a Pandemic Influenza reservoir. Numerous accounts of important revisions are on record across a vast geography. The HA gene segment provides suitable examples for this discussion. 225G has produced a Vaccine Escape event in LvivN6, an elevated Case Fatality Rate and a substantial number of severe outcomes. Individual changes from 157 to 159 have also demonstrated “low reactor” status and registered as Vaccine Escape events. When 230I entered the H5N1 Gharbiyah cluster in Egypt, the resultant Case Fatality Rate became 80% for that strain, a substantial increase from the accepted H5N1 CFR.
Three separate single genetic changes are well characterised in leading to various forms of Anti-Viral resistance. TamiFlu Resistance (TmX) has now dispersed widely in a pattern following the rapid spread of resistance in seasonal influenza via the same Single Nucleotide Polymorphism coding for 275Y on the Neuraminidase. Emergent and attractant H1N1 strains (Triple Reassortments again) co-circulating alongside the pandemic reservoir also carry 275Y. H5N1 inclusions increase in the pandemic reservoir with a continuous flow. The PB2 627K is confirmed as leading to increased replication speed in humans and has recently been documented in a second pandemic sequence. As we have maintained from the beginning of this pandemic, TamiFlu Resistance and 627K are foregone conclusions according to our calculations.
Our team noted an increase in Avian inclusions and recently predicted HA 230I for ΣPF11. The polymorphism was documented last week in Wisconsin (US) on a background that does not deter transmission. The geographic area has a notable increase in cross-linked activity. The individual sample, A/Wisconsin/629-D00337, is primed for spread with 2 additional HA markers, 275A (TX, NM, CA and Sweden) and 377K (aggressively emerging). The NA carries 220K, a marker found on one cross-linked sequence from the Ukraine and across a wide US geographic pattern from December 2009 to the most recent 2010 sequences (North Carolina, New Hampshire, Wisconsin and Nebraska). The H6N1 Avian reservoir conserves 220K on the NA of 6 samples. We consider the Wisconsin0337 sample to be an excellent candidate as a universal donor of sorts due to limited polymorphisms, FlightPath intersecting location and the fact that each revision is currently an emergent change.
A second variant of 230I has been recorded from southern China with A/Guangdong/2282. Though the underlying 230I nucleotide coding and the overall background is different from the Wisconsin0337 sequence, Guangdong2282 remarkably carries the extremely rare 275A, a permutation found in less than ten samples within this pandemic reservoir. Guangdong2282 displays a highly polymorphic HA with 131P, 202A, 230I, 244I and 275A. All but 131P are rare. 202A is only found on one other human pandemic sequence, a 2010 TamiFlu Resistant case from Mexico. Two of the four NA changes match 1918 (53I, syn315G) with potential H5N1 involvement on one other. Convergence of numerous rare polymorphisms, including potential acquisitions from H5N1, H6N1, H9N2 and 1918, informs us that the viral reservoir is amply supplied for variation and is adamant about exercising fresh patterns.
H9N2, a "bird flu" serotype, has been recently evaluated for human pandemic potential. By all appearances, the present H9N2 reservoir is not becoming a pandemic virus, but is very much influencing the genetic acquisition cycle of the currently circulating PF11 pandemic virus (pH1N1). Which is worse, another species-jumping serotype entering the fray or a combinational virus with genetics from multiple pandemic potential reservoirs appending onto the current partially-adapted virus? In either case, the Hydra Effect appears to be operating in full force.
Given this information, obvious questions begin to form. If one genetic change may potentiate variant clinical outcomes, drug resistance or Vaccine Escape, what is the potential for multiple changes producing a variant outcome? And if a single genetic change and/or multiple changes are capable of producing large changes in behaviour, should we, in turn, have a very high and accurate level of surveillance on this reservoir? And what should we do with that important information? Should our public health officials speak from a platform of candor and accuracy when carrying out the responsibilities of their trusted positions?
Let’s investigate now if the viral reservoir is, in fact, unchanged?
Approximately 86% of the Hemagglutinin positions between 186 and 244, including antigenic areas of the RBD, are on record as polymorphic. Only 8 positions in that range are stable. Many positions rate multiple changes. The list presented today is certainly not comprehensive. For the sake of brevity, only one section is discussed from one gene segment (HA) covering just 59 amino acid positions. The extensive variation in that short range is documented in the trailing data. Tracking these revisions against various baselines has informed our studies over the past year.
The positional summary may perhaps be instructive for those who hold the belief that the pandemic reservoir is stable. This report may provide reversing guidance for those who make public statements to the effect that pandemic H1N1 is not changing. Although their multiple motivations to transmit these types of false “Feel Good” statements are somewhat discernable, the citizen requires the full story, the truth, to make informed decisions.
Those making these statements do, in fact, understand Primary Logic and Basic Science; they do know that for a vaccine to be considered widely useful, the viral reservoir must be cooperative and unchanging. They also know that this reservoir is vastly changed. However, their jobs depend on providing a social message with a stated solution. Knowing that the vaccine is not useful against this present changed virus, they must by now realise that they have lost their stated solution. The traditional public health strategy in these solution-less situations is obfuscation. Re-education on basic fact, re-definition of truth, has now become the chief tenet, their tool of choice, to bridge that failure to solve.
Science solves . . . crafting a clever press release is not an act of science.
The official repetition of the “All Clear” social messaging campaign cannot reverse the weight of the actual data. The presently circulating virus is hereby documented in this report as changed and changing. No amount of repetition invoking the “unchanged” myth, that mystical “Feel Good” chant, can conjure an environment that miraculously creates a stable viral reservoir or that alters the ongoing genetic acquisition cycle.
However, that ongoing strategy of repetition is apparently very effective in managing the perception and manipulating the belief of the unsuspecting public. Sleight of hand is always discovered on careful observation . . . but will this reliance on myth be discovered soon enough?
Observe.
The viral reservoir backing this present H1N1 pandemic is far from stable and is actively acquiring new genetics. Current data does not indicate an immediate direction toward stability.
As is the nature with an IDRREAV, the positions reported here will not necessarily be the most important amino acid positions in the future. The reservoir will evade immunity and escape vaccine by heavily self-revising in the near future at key locations between 131 and 182 (emphasis at 155 to 177). Variation will occur with lower penetration at the head of the HA and from 272 downstream approximately 55 positions. Potential is very high that 22I will achieve density in one or more sub-clades. Expect 100N to spread and penetrate initially on sub-clades without the 22I appearances. South American polymorphisms from their fatal mid-pandemic strains of 2009 will recycle into the United States and other Northern Hemisphere nations with substantial thrust in the coming 90 days. Acceleration of the Avian based cross-linking will continue in the Western world.
Bear in mind also that a solid portion of the changes documented in this current list will become fixed even as additional donations are accumulated. The zoonotic movement from birds into human PF11 sequences is earnestly progressing in the most recent 45 days of available data. Several polymorphisms, HA and NA, from the recent 2010 Georgia hospitalization resurgence may have originated in Avian Influenza samples.
Expect continued acquisition from Avian H5N1, H6N1 and H1N1, and also watch the acceleration from one particularly new Avian donor serotype. H9N2 demonstrated a human jump in late 2008 and has very recently become fully engaged in ΣPF11 genetics with a well-defined etching on the newest cross-linked sequences. The reservoir flux will also be influenced by Swine H1N2 and H1N1 (emphasis on 3 certain emergent strains).
Is the Pandemic Influenza Reservoir Stable?
You decide . . .
186S synonymous (TCc) Russia61, BZSP53823_2009_08_01_f,
. . . . BadenWurttemberg8_2010, TexasJMS387_2009_12_08,
. . . . KO_Daegu1873_2009_12_16_TmX,
. . . . H9N2 (cCc, cac)
186P (cCT) CalifVRDL7, UkraineChernihiv857, Ankara17
186F (TtT) Ankara26
187T synonymous (ACc) Berlin164, S5, 1918, H9N2
187A (gCT) TexasJMS405_2009, TexasJMS406_2009, H5 (gaT)
188T swThaiCURA75_2010_01
188N SC16, SC31, NY3502, ME15, CatS1187, Milan433, Kaifu4142,
. . . . Japan, Bilthoven4360903023, S5, H5
188I Growing in US on cross-linked background (4), BZSP53823 (186S),
. . . . H1N1 (1943, 46, 51)
189V Sydney2503, Texas46172731, H6N1 mallMaryland887_2002, Sask
189S Wisc1434
189T Extensive in US, on cross-linkage (4), Ontario328474
. . . . H5N1 2009, H6N1, H9N2 2008
189A synonymous (GCc), Georgia01_2010, Georgia 2010 (+5), swOR4060
190D synonymous (GAt) Nebraska02_2010, Milan326, UkraineZakarpatska830,
. . . . 1918, H1N1 (1943, 51)
190Y SwedenMalmoe1_2010_01_01, H6N1 (tTG)
191R Chengdu18 (131P), GuangdongSWL28
192H GuangdongSWL28
192Q synonymous (CAg) RomaISS50, Nebraska01_2010, H1N1 (1943, 46)
193S synonymous (AGc) SC18, US 2010 (4), Milan294, Japan, H9N2
193G (gGT) AR08, Cal_SDINS04
193N Washington72, H9N2
193R (cGT) catItaly304678_1_2009_12_17_f
194I NC38E3, VA27, SC18, Bangladesh3009, StPete59, StPete99
194L synonymous (CTa) Japan4081, tn
. . . . H9N2 2008 (tTa), H6N1 chkTaiwan1205_2001 (CTa)
194L synonymous (CTt) TexasJMS385_2009,
. . . . H9N2 dkVietnamOIE2327_2009
196Q synonymous (CAa) Wisc (3), Moldova (3), Malaysia (2), Milan326,
. . . . Pavia (6), Ankara18, NordrheinWestfalen106, swOR4060
197T Malaysia4039
198A synonymous (GCc) KO_Seoul1870_2009_12_18_TmX
198V Malaysia5283, Malaysia9117
199N GuangdongSWL28, Milan80, Milan83, S9, S7, M7, Sask, H5 (aCT),
. . . . H1N1 (1943, 46, 51) (aCT)
199D synonymous (GAc) swine Illinois, H5, H9N2
200A synonymous (GCc) swOR4060, S5
200T (aCA) FL31, RomaniaTimis2018, Australia (6), Asia (13),
. . . . MilanUSHR1, Bilthoven4360901004,
. . . . ShizuokaC247_2009_11_08, H5, KO_Seoul1785_2009_11_TmX,
. . . . tkDeutsche, swDeutsche,
. . . . H9N2
200S (tCA) NC57, SC46, WiscD0780, WiscS1338, NY5276, NJ11,
. . . . DC_INS31, cheetahCA30954
201H (cAT) Wisc1140, Darwin2140, H3N8 (cAa, cga), H7N7 (cta, ctg)
202A (GcT) MXinDRE797 2010 TmX (280A, syn321L, 324I), IA14, KY25,
. . . . HK34360, Guangdong2282 (230I, 275A),
. . . . Bilthoven4310901550 (89G), Bilthoven4360903104 (89G),
. . . . H9N2 (AcA, AcG)
202V synonymous (GTc) YAMAGATA778, YAMAGATA803, swIllinois,
. . . . H1N1 (1943, 46, 51)
204V synonymous (GTa) PA31, SHIZUOKA1573, 1918, S7
204V synonymous (GTa) TexasJMS367_2009_11_12, PA31,
. . . . Shizuoka1573, Niedersachsen34, RheinlandPfalz86,
. . . . 1918, S9, S7, M7, Sask,
. . . . H9N2 Israel 2009, H9N2 Iran 2008
205E (GaG) BadenWurttemberg8_2010, ShizuokaC247_2009_11_08
. . . . Alabama03_2010_03_01 mix,
. . . . H11 (Gat), H7N7 (Gaa), H7N7 dkVictoria1976 (GaG)
205G synonymous (GGa) Texas76C2, Wisc (4), tkDeutsche, swDeutsche,
. . . . S5, H3N8 (tCa), H9N2 (GCa), H6N1 (GGa), H7N7 (GGa)
206A CatS1161
206T Extensive
207S synonymous (TCg) California01_2010
208K US, UK, Canada, HK, MX, Italy (2), Australia (12), Asia (3), swOR4060
208S Australia43, Australia45, H6N1
208G NY6292
208T Norway3440
208R synonymous (AGg) TexasJMS385_2009
209D NorthDakota15
210G (gGC) Bilthoven4360903119 (225E)
210S synonymous (AGt) Bogota0466N, Malaysia9131, H9N2 (Aat)
210N Texas76C2, H1N1 (1943, 46, 51)
211K synonymous MXinDRE50617 (225G)
211R swOR4060_2009_12_31, 1918, H1N1 (1943, 46, 51)
212R swOR4060_2009_12_31, 1918, H1N1 (1943, 46, 51)
212E Vlad01 (225G), Argentina8574_41, IN21, HI30, Malaysia4039
212N ME15
212T Anadyr177_F (225G), CA07X179, CA07X181
212K synonymous (AAa) TexasJMS404_2009
213L TX15, Iowa04_2010, H5
213F synonymous StPete99 (225E)
214E Kurgan01, Moldova (3), swOR4060_2009_12_31
214N ENG92960012, SHIZUOKA1514, Hessen48
214Q Wisc0936 (237L)
214K synonymous (AAa) San DiegoINS101_2009, NM13, CatS1937,
. . . . ENG620, China22811, S5, H9N2
215P synonymous (CCa) San DiegoINS101_2009, SC33, Eng616,
. . . . GuangdongyunchengSWL51, BZ_Bahia15525_42M_f (RRT)
215P synonymous (CCt) NY_WC37RG, MO02, Eng256
216E synonymous (GAg) BadenWurttemberg490_xL, Hamburg14_xL,
. . . . Thuringen189_xL, Thuringen227_xL, Bilthoven4360903109,
. . . . Moldova (4), Belarus, Bosnia (3, 225G), Indiana, tn, H9N2 (GTg)
218A synonymous (GCg) Belarus, H9N2 (GGg), H6N1
218A synonymous (GCt) Nebraska02_2010
218E Texas77 (159S, syn173G, 275A, 377K, 454I)
218S (tCA) Georgia07_2010 mix
218T Hiroshima201 (225G)
218V (GTa) GuangdongyunchengSWL51, Malaysia (2 mix wt)
218V (GTc) swIll02930, 2931, 2932, 2937 (2009-12-29, 30)
219I synonymous (ATt) Cal_SDINS35, Ancona451_f, Lyon2490,
. . . . RheinlandPfalz81, Berlin210, BadenWurttemberg511,
. . . . H5 (Act), H6N1 (gct, gat)
219T (AcA) Wisc0134 (225E), Ontario315107 (225E), RomaISS223,
. . . . Korea3623_2009_11_09 (131P, 226R, 280A), swOR4060_2009_12_31
220R synonymous (AGg) Mexico476, Malaysia9451, H6N1
223V synonymous (GTa) Utah59, H1N1 (1943, 46, 51),
. . . . H6N1 mallSweden30_2005
223M CA33
224K SC18_VxX, Melbourne1_1946
224M NY5186
225N BZ_SP53838, Ukraine mix wt, Victoria2125, Malaysia8860 et al
225E Extensive on multiple backgrounds
225G LvivN6_VxX with syn413K, UkDnip273 (GgT mix wt),
. . . . H1N1 (1943, 46, 51), H9N2, H6N1
225G RomaISS1897 & 1941, EgyptVacsera138 (300S) ex225E (Gga), H6N1
225E+226R Russia (3), GermanyBY74, swMX4
226R Alabama01_2010, Trabzon01 (Turkey), GermanyMVHGW4_2009_12,
. . . . Korea3623_2009_11_09 (131P, 280A), catItaly304678_2_2009_12_17_f, et al
227A swOR4060_2009_12_31, NJ11_1976_X53A, 1918,
. . . . H1N1 (1943, 46, 51)
227V RomaISS50
227G Utah20 with wt mix
229R synonymous (AGg) swMX04 (225G, 226R), H6N1
230I Wisc0337_2009_12_15 (275A), Guangdong2282 (131P, 202A, 275A),
. . . . H1N1 (1943, 46, 51), H5 Gharbiyah 80% CFR, H9N2, H6N1
230V (gTG) TexasJMS369_2009
231D Ankara05, OSAKA2143, H9N2 2008, H6N1
231N CalifVRDL36
231K Wisc0853, Wisc1915, Wisc2337
232Y synonymous (TAc) TexasJMS386_2009, Florida30, PuertoRico51, S9, S7, M7, Sask,
. . . . H9N2, H5, H6N1
233Y synonymous (TAt) AthensINS85, Hiroshima645, H9N2 2008, H6N1
233H NC Duke (5, wt, 225G, 225N), AZ17 & Australia6
235A CatNS7632, CalifVRDL55
235I Wisc2489
236L synonymous (CTg) Wisc0099, H9N2 (gTg)
236V Eng93120020, ENG645, H9N2, H6N1
237I Delaware02_2010, Cal_SDINS69, England (2), Russia (4), Asia (2)
237L Wisc0936 (214Q), 1918, H1N1 (1943, 46, 51),
. . . . tn, H5, H9N2, H6N1
237V synonymous (GTg) Pennsylvania31, H9N2 (TTg), M7 (CTg)
238D Kaliningrad01 (225E+226R), tn
238K (aAG) Wisc2485 (225E), Spain (2), China,
. . . . OrenburgIIV13_2010_03_02_xL_f (225G), swOR4060,
. . . . Iowa_1943, H5, H9N2 2008, H6N1
238E synonymous (GAa) Extensive Wisc2424, SC01_2010, MN01_2010,
. . . . H9N2 (aAa), H6N1 (aAa)
239P synonymous (CCt) ENG621, swOR4060_2009_12_31
239P synonymous (CCa) Ancona508PG, Russia180, Australia60, ME01_2010, tn,
. . . . H9N2, H6N1
240G synonymous (GGg) DC_INS24, H9N2, H6N1 (GGg), S9, S7, M7, Sask
240G synonymous (GGc) Wisc0636, H9N2 (GGc)
240E (GaA) Brandenburg34
241D synonymous (GAt) CatS1943, tn
241G NH17, ENG93040048
241E China22811, H9N2 (CAa, CAg), H6N1 (GAa, GAg)
242K synonymous (AAg) swOR4060_2009_12_31
244I ThaiCU_H9, Guangdong2282 (131P, 202A, 230I, 275A), Shiga1,
. . . . Ancona02, Stockholm29,
. . . . Alabama03_2010, H1N1 (1946, 51), S9, S7, M7, Sask
244T synonymous (ACt) CatS1935, CatS2120
The truth is in the sequences.
Friday, March 26, 2010
Apollo turbine based spray paint systems.
From: Tim Wallick
Apollo Import and Export
I would, like to take a few minutes of your valuable time. To introduce you within Egypt to a concept in paint equipment. Along with some of our related line of products. True HVLP Technology from Apollo sprayers.
Were the local Authorized Agent / Representative for Apollo's full line of high quality, cost effective High Volume Low Pressure turbine paint spraying systems along with the related hvlp spray guns.
Would you like to achieve better results. Cost effectively every time when spraying. Epoxy, enamels, stains, lacquers, polyurethanes, latex, glue's, catalyzed materials, conversion varnishes and linear polyurethanes to name a few. Are you tired of seeing your costly paint material's swept from the floor in the form of waste? Would you like to stretch how far each litter of paint can go?
The Apollo system atomizes and delivers the paint to the article using a minimum of 3.5 PSI (0.24 BAR) to a maximum of 10 PSI (0.69 BAR) depending upon the type of material selected and the viscosity. The low pressure used, results in the elimination of overspray. Along with the related rework and wasted material do to dispersion into the atmosphere. Conventional, compressor supplied paint systems are one of the least economical to operate do to waste, along with the environmental impact do to the system design.
This system has, No air compressor or dryer or filters to maintain that’s correct "no air compressor or dryer" or the related problems of water and oil contamination of the paint. This contamination enters the paint stream directly from the output line on the compressor. This always results in great expense, Do to rework and possible schedule delays.
The high quality Apollo system utilizes a built in turbine motor to drive and deliver the paint and air supply to the gun tip for atomization. The Apollo line of paint guns are user friendly and very low maintenance. The Series 5500 production spray gun has only twenty three total parts. Each Apollo spray gun comes with a written two year warranty on materials and workmanship.
The Spray guns included in Series 5000, 7000 & 8000 Have a certified "minimum transfer efficiency rating of 65%" and meets or exceeds all known government codes for transfer efficiency throughout the United States including California.
Apollo's Hvlp turbine systems are light weight. The smaller units can be carried by a single person. The weight of the smaller model is only 8.6kg. The largest model comes mounted on a base with wheels and weighs 40.4kg and can supply air to three spray guns simultaneously using the standard 2.5 gallon (ten liter) Teflon coated fluid tank and two cup guns. Every model requires a grounded power outlet to supply 220-240 volts at 50 Hz.
Business Managers, Can now say goodbye to overspray, water and oil related trouble during your painting operations! While you lower your total maintenance expense for your painting operation. All while you benefit by depositing a greater percentage of paint directly on the article.
If your thinking of upgrading your paint operations, or building a new facility. Consider seriously viewing this equipment during operation in your factory. It will help you truly understand the full range of benefits provided by this technology.
Feel free to contact us to arrange for a personal consultation to further discuss the full range of real benefits from Hvlp Technology from Apollo Sprayers. Were available for consultation and assistance on other paint related problems you may be having within your current manufacturing, cleaning and paint operation.
Sincerely Tim Wallick
Apollo Import and Export (New Maadi)
Building twenty, Ahmed Kamal St. (Next to US-aid)
Office: 02 26876932 Mobile: 012 324 7027
Email: Timewallick@Msn.com
Arabic please contact Mahmoud Wahba 0124800352
Apollo Import and Export
I would, like to take a few minutes of your valuable time. To introduce you within Egypt to a concept in paint equipment. Along with some of our related line of products. True HVLP Technology from Apollo sprayers.
Were the local Authorized Agent / Representative for Apollo's full line of high quality, cost effective High Volume Low Pressure turbine paint spraying systems along with the related hvlp spray guns.
Would you like to achieve better results. Cost effectively every time when spraying. Epoxy, enamels, stains, lacquers, polyurethanes, latex, glue's, catalyzed materials, conversion varnishes and linear polyurethanes to name a few. Are you tired of seeing your costly paint material's swept from the floor in the form of waste? Would you like to stretch how far each litter of paint can go?
The Apollo system atomizes and delivers the paint to the article using a minimum of 3.5 PSI (0.24 BAR) to a maximum of 10 PSI (0.69 BAR) depending upon the type of material selected and the viscosity. The low pressure used, results in the elimination of overspray. Along with the related rework and wasted material do to dispersion into the atmosphere. Conventional, compressor supplied paint systems are one of the least economical to operate do to waste, along with the environmental impact do to the system design.
This system has, No air compressor or dryer or filters to maintain that’s correct "no air compressor or dryer" or the related problems of water and oil contamination of the paint. This contamination enters the paint stream directly from the output line on the compressor. This always results in great expense, Do to rework and possible schedule delays.
The high quality Apollo system utilizes a built in turbine motor to drive and deliver the paint and air supply to the gun tip for atomization. The Apollo line of paint guns are user friendly and very low maintenance. The Series 5500 production spray gun has only twenty three total parts. Each Apollo spray gun comes with a written two year warranty on materials and workmanship.
The Spray guns included in Series 5000, 7000 & 8000 Have a certified "minimum transfer efficiency rating of 65%" and meets or exceeds all known government codes for transfer efficiency throughout the United States including California.
Apollo's Hvlp turbine systems are light weight. The smaller units can be carried by a single person. The weight of the smaller model is only 8.6kg. The largest model comes mounted on a base with wheels and weighs 40.4kg and can supply air to three spray guns simultaneously using the standard 2.5 gallon (ten liter) Teflon coated fluid tank and two cup guns. Every model requires a grounded power outlet to supply 220-240 volts at 50 Hz.
Business Managers, Can now say goodbye to overspray, water and oil related trouble during your painting operations! While you lower your total maintenance expense for your painting operation. All while you benefit by depositing a greater percentage of paint directly on the article.
If your thinking of upgrading your paint operations, or building a new facility. Consider seriously viewing this equipment during operation in your factory. It will help you truly understand the full range of benefits provided by this technology.
Feel free to contact us to arrange for a personal consultation to further discuss the full range of real benefits from Hvlp Technology from Apollo Sprayers. Were available for consultation and assistance on other paint related problems you may be having within your current manufacturing, cleaning and paint operation.
Sincerely Tim Wallick
Apollo Import and Export (New Maadi)
Building twenty, Ahmed Kamal St. (Next to US-aid)
Office: 02 26876932 Mobile: 012 324 7027
Email: Timewallick@Msn.com
Arabic please contact Mahmoud Wahba 0124800352
Sunday, March 21, 2010
Egypt, US seek boosting trade exchange
Yes Egypt has long been considered third world, relative to many other countries.That said it's recent history clearly indicates other wise.Business is expanding across all sectors.Real opportunity exist to expand a company's reach into the middle east area using the concept/vehicle mentioned below.
Business leaders across America should consider sending a portion of they're management personnel on a working vacation to explore what could be a excellent way to develop deeper,stronger cultural and business ties in this very important part of our global community.
Were currently performing a operational review of a family owned paint and adhesives manufacturing facility it is a smaller operation by global standards.This firm leads the egyptain market with two of its primary products they produce.
Sunday, 21 March 2010
Egypt, US seek boosting trade exchange
US Assistant Secretary of Commerce Suresh Kumar underlined the importance of promoting US-Egyptian trade relations.
During his participation in a meeting in Washington with members of the Arab American Chamber of Commerce, Kumar said trade relations binding Egypt and the US should further develop.
According to Kumar, Egypt ranks 34th on the list of US trade partners which does not commensurate with US-Egyptian relations.
The US official said Egypt has great opportunities that would enable it to merge into world trade, especially following reform measures introduced by the government.
Egypt has great potentials that could help the country secure a better rank among countries enjoying high volume of trade with the US, he added.
Business leaders across America should consider sending a portion of they're management personnel on a working vacation to explore what could be a excellent way to develop deeper,stronger cultural and business ties in this very important part of our global community.
Were currently performing a operational review of a family owned paint and adhesives manufacturing facility it is a smaller operation by global standards.This firm leads the egyptain market with two of its primary products they produce.
Sunday, 21 March 2010
Egypt, US seek boosting trade exchange
US Assistant Secretary of Commerce Suresh Kumar underlined the importance of promoting US-Egyptian trade relations.
During his participation in a meeting in Washington with members of the Arab American Chamber of Commerce, Kumar said trade relations binding Egypt and the US should further develop.
According to Kumar, Egypt ranks 34th on the list of US trade partners which does not commensurate with US-Egyptian relations.
The US official said Egypt has great opportunities that would enable it to merge into world trade, especially following reform measures introduced by the government.
Egypt has great potentials that could help the country secure a better rank among countries enjoying high volume of trade with the US, he added.
Saturday, March 13, 2010
China will screen Egyptians for flu symptons starting in three months.
trey-fish from Flutracker.com whom follows china and other areas found this article yesterday.
Flu trackers has an Arabic section for Egypt which goes almost un-used it would be nice to have some help with the posting of Arabic information.any body with a interest can contact flu trackers via this link
the site is always looking for volunteer profession people that are related to the types of issues which are followed at flu-trackers.
Friday, March 12, 2010
China issued notice against Egypt and other people infected with highly pathogenic bird flu from spreading
At 21:18 on March 12, 2010 Source: China News comments
China news agency, Beijing, March 12 (Reporter Liu Changzhong) - China State Administration of Quality Supervision, Inspection and Quarantine issued a public notice this evening to prevent countries such as Egypt and Indonesia, people are infected with highly pathogenic bird flu into China.
World Health Organization (WHO) 2 24 and 26 reported so far Indonesia has confirmed 163 cases of human infection with highly pathogenic avian influenza H5N1 cases, including 135 cases of death; Egypt confirmed 99 cases of human infection with highly pathogenic avian influenza H5N1 cases, 30 cases had died. Recently, the two countries have continued to bird flu confirmed cases, and appears dead.
In order to prevent human infection with highly pathogenic influenza A H5N1 bird flu into China, protecting China to Egypt and Indonesia, workers health and safety, according to "The People's Republic of China Frontier Health and Quarantine Law" and its Implementing Regulations of the relevant provisions of China's national quality inspection General notice requirements, the personnel from Egypt or Indonesia, if fever, cough, headache, general malaise and other symptoms, and immigration should take the initiative to an oral declaration of entry-exit inspection and quarantine authorities; after entering the above symptoms, it should be immediate medical treatment to the doctor explain the recent travel history to receive timely diagnosis and treatment.
pandemicinformationnews
Flu trackers has an Arabic section for Egypt which goes almost un-used it would be nice to have some help with the posting of Arabic information.any body with a interest can contact flu trackers via this link
the site is always looking for volunteer profession people that are related to the types of issues which are followed at flu-trackers.
Friday, March 12, 2010
China issued notice against Egypt and other people infected with highly pathogenic bird flu from spreading
At 21:18 on March 12, 2010 Source: China News comments
China news agency, Beijing, March 12 (Reporter Liu Changzhong) - China State Administration of Quality Supervision, Inspection and Quarantine issued a public notice this evening to prevent countries such as Egypt and Indonesia, people are infected with highly pathogenic bird flu into China.
World Health Organization (WHO) 2 24 and 26 reported so far Indonesia has confirmed 163 cases of human infection with highly pathogenic avian influenza H5N1 cases, including 135 cases of death; Egypt confirmed 99 cases of human infection with highly pathogenic avian influenza H5N1 cases, 30 cases had died. Recently, the two countries have continued to bird flu confirmed cases, and appears dead.
In order to prevent human infection with highly pathogenic influenza A H5N1 bird flu into China, protecting China to Egypt and Indonesia, workers health and safety, according to "The People's Republic of China Frontier Health and Quarantine Law" and its Implementing Regulations of the relevant provisions of China's national quality inspection General notice requirements, the personnel from Egypt or Indonesia, if fever, cough, headache, general malaise and other symptoms, and immigration should take the initiative to an oral declaration of entry-exit inspection and quarantine authorities; after entering the above symptoms, it should be immediate medical treatment to the doctor explain the recent travel history to receive timely diagnosis and treatment.
pandemicinformationnews
Monday, May 25, 2009
Egypt Cairo Inside
Cairo Inside.
I spent my first couple of months living in the Sonesta chain,which was located just off the main road coming from the airport. I found the hotel to be acceptable and the staff very helpful.It was a business type hotel with a very good mix of dining areas and most carry the local wines which were nice and come from the Geniclise area of Egypt. which means grape in English. The wines also make a very simple good gift.Cairo and greater Egypt, truly are worth visiting.
Meeting the Egyptian people away from the tourist industry.Will surely show you a wonderful culture. Based on my life here.That when combined with some of the common simple everyday foods will only add to your stay becoming a positive visit to this wonderful country as mine has been.
Everything here takes place at a much slower pace, time really can seem to be un-important within our daily life.When visiting the country side and small villages one often meets up with the pride of Egypt found with in the hospitality of a simple farmer. That's willing to share hot tea with you and maybe, he even elects to honor all mankind by offering to share a family meal with you.
During your planed travels through out Egypt never eat from the Donkey carts along the roadways.
Wednesday, April 8, 2009
Building Business growing in Egypt
Well its been a while and the building industry and manufacturing appears to be on the mend within egypt. The price of steel rebar has declinded by one hundred and fifty percent. With buildings being worked on again, it was a very bad period just short of nine months.
Recently I spent a morning with a gm egypt supplier of painted bumpers and mirrors.I was quite impressed with how well the facility was organized and operated. While they currently use another manufactures Hvlp conversion guns for their paint operations. It was nice to see a service provider of such a high quality operation. Applying the total skill set correctly within its painting operations. The facilities efforts have resulted with general motors,awarding an increase in the firms total daily percentage share of required all required items.
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